Dynamics of the dopaminergic system as a key component
to the understanding of depression
Yadid G, Friedman A.
The Mina and Everard Goodman Faculty of Life Sciences
Leslie and Susan Gonda (Goldshmied) Multidisciplinary Brain Research Center,
Bar-Ilan University, Ramat-Gan 52900, Israel.
Prog Brain Res. 2008;172:265-86.
ABSTRACTFor decades, clinical treatment of depression has usually involved antidepressants that target noradrenergic and serotonergic neurotransmission. Over the past half century, no genuinely ground-breaking progress has been made in the pharmacological development of antidepressant drugs. Dopaminergic mesolimbic and mesocortical systems are involved in hedonia and motivation, two core symptoms of depression. However, their role in the pathophysiology of depression and their manipulation to treat depression has received little attention. Recent findings indicate the potential usefulness of monitoring limbic dopaminergic dynamics in combination with mathematical analysis. In this chapter comprehensive review of data from animal models, genetics, neuroimaging and human clinical trials that strengthen the case for dopaminergic dysfunction in the pathophysiology of major depression. This chapter focuses on recent convergence of data describing the fluctuation in activity of the mesolimbic dopaminergic system, and discusses its crucial role in manifestation of depressive-like behavior. Decoding the functionality of the dopaminergic system is important to the understanding of depression and the development of future efficient antidepressant treatments.Biohappiness
Eugenics before Galton
The literature of eugenics
Germline genetic engineering
Preimplantation genetic diagnosis
A life without pain? Hedonists take note'
Francis Galton and contemporary eugenics
Hyperthymic and depressive temperaments
Gene therapy and performance enhancement
5-HTT and AP-2beta gene polymorphism/spirituality
and further reading
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
MDMA: Utopian Pharmacology
Critique of Huxley's Brave New World