R.A. Fisher's contributions to genetical statistics

by

Thompson EA.

Department of Statistics,

University of Washington,

Seattle 98195.

Biometrics. 1990 Dec;46(4):905-14.

ABSTRACTR. A. Fisher (1890-1962) was a professor of genetics, and many of his statistical innovations found expression in the development of methodology in statistical genetics. However, whereas his contributions in mathematical statistics are easily identified, in population genetics he shares his preeminence with Sewall Wright (1889-1988) and J. B. S. Haldane (1892-1965). This paper traces some of Fisher's major contributions to the foundations of statistical genetics, and his interactions with Wright and with Haldane which contributed to the development of the subject. With modern technology, both statistical methodology and genetic data are changing. Nonetheless much of Fisher's work remains relevant, and may even serve as a foundation for future research in the statistical analysis of DNA data. For Fisher's work reflects his view of the role of statistics in scientific inference, expressed in 1949: There is no wide or urgent demand for people who will define methods of proof in set theory in the name of improving mathematical statistics. There is a widespread and urgent demand for mathematicians who understand that branch of mathematics known as theoretical statistics, but who are capable also of recognising situations in the real world to which such mathematics is applicable. In recognising features of the real world to which his models and analyses should be applicable, Fisher laid a lasting foundation for statistical inference in genetic analyses.H.W. Poll

Biohappiness

Eugenics talk

'Designer babies'

Private eugenics

Psychiatric genetics

'Liberal eugenics' (PDF)

Human self-domestication

Selecting potential children

Preimplantation genetic diagnosis

'The Principle of Procreative Beneficience'

Francis Galton and contemporary eugenics

Gene therapy and performance enhancement

The commercialisation of pre-natal enhancement

Biologising social problems under the banner of eugenics

Refs

and further reading

HOME

Resources

Wireheading

BLTC Research

nootropic.com

Superhappiness?

Utopian Surgery?

The Good Drug Guide

The Abolitionist Project

The Hedonistic Imperative

The Reproductive Revolution

MDMA: Utopian Pharmacology

Critique of Huxley'sBrave New World